个人简介
张帅帅，博士，脑科学与康复医学研究院青年英才，2023年7月入职。博士毕业于厦门大学，师从曾锦章教授；在南方医科大学完成博士后训练，合作导师为毕惠嫦教授。目前主要运用组学测序、基因编辑及合成生物学等技术，开展纤维化、炎症和肿瘤相关的细胞信号转导机制与工程化免疫细胞治疗研究，探索新型治疗策略。近年来主持了国家自然科学基金青年项目、中国博士后科学基金面上一等资助项目，代表性研究成果发表在Science Advances, Military Medical Research, Cell Reports, Pharmacological Research, Theranostics等期刊。
邮箱：zhangshuai2@smu.edu.cn；zhangshuai2@scnu.edu.cn
附：主要论文成果
(#: equal contribution; *: corresponding author)
1. Chen K#, Fu Q#, Zhang W#, Lin Z, Chen L, Zhou Y, Huo Y, Gao Z, Wan H, Wang C, Huang X, Zhang S*, Liu M*, Ma X*. Extracellular matrix-targeted TNC-scFv armoring enhances CAR T cell persistence and antitumor activity in solid tumors. Science Advances. 2026 Oct 9;12(41):eaeh3957.
2. Chen K#, Lin Z#, Chen L, Zhou Y, Zhang W, Wan H, Huo Y, Fu Q, Gao Z, Cheng H*, Ma X*, Zhang S*. TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice. Mil Med Res. 2025 Nov;12(1):78.
3. Zhang W#, Chen K#, Ke Y#, Yan D, Lin Z, Chen L, Gao Z, Shen Y, Wan H, Yang X, Hu C, Chen R*, Ma X*, Zhang S*. Spatial and single-cell transcriptomics reveals senescence-associated changes in MIA-induced ASD male mouse brain. Cell Reports. 2026 Mar; 45(4), 117191.
4. Zhang S#, Guo M#, Jiang X, Tang L, Wu T, Bi G, Yang X, Fan S, Bi HC*. PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Pharmacol Res. 2023 Feb;188:106666.
5. Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H*, Zeng JZ*. The Roles of GSK-3b in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Theranostics. 2020 Jan 1;10(3):1230-1244.
6. Zhao K#, Zhang S#, Tian J#, Wu S, Chen Y, Wu Z, Liang J, Wu H, Pang J*, Wu T*. Loss of Urat1 exacerbates APAP-induced liver injury in mice. Toxicology. 2025 Feb;511:154070.
7. Zhou Y#, Chen K#, Cheng H*, Zhang S*. Recent Advances in Polysaccharide-Based Hydrogels for Tumor Immunotherapy. Gels. 2025 Feb;11(3):152.
8. Lai S#, Wang P#, Gong J*, Zhang S*. New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis. PeerJ. 2023 Dec;11:e16635.
9. Zhou Y#, Chen K#, Zhang Y, Cheng H*, Zhang S*. Adoptive cell therapy for HBV-associated liver diseases. Biomedical Technology. 2025 Nov;12:100116.
10. Tian J#, Zhang S#, Li L, Lin X, Li Y, Zhao K, Zheng F, Chen Y, Yang Y, Wu T*, Pang J*. Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-kB p65 pathways. Exp Biol Med (Maywood). 2023 Oct;248(20):1864-1876.
11. Shi Z#, To SKY#, Zhang S#, Deng S#, Artemenko M, Zhang M, Tang J, Zeng JZ*, Wong AST*. Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition. Theranostics. 2021 Jan 19;11(7):3376-3391.
12. Cao L#, Zhu Y#, Wang W, Wang G*, Zhang S*, Cheng H*. Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy. Front Bioeng Biotechnol. 2021 Dec 7;9:798882.