个人简介
张帅帅，博士，南方医科大学出站博士后（合作导师：毕惠嫦教授），博士毕业于厦门大学（硕博连读，导师：曾锦章教授）。2023年7月加入华南师范大学脑科学与康复医学研究院，特聘研究员。感兴趣的研究方向为分子药理学及细胞信号转导，重点关注核受体在肿瘤发展、肝脏再生等方面的调控机制及药物开发潜力，相关研究成果发表在Theranostics，Pharmacological Research，Cancers等杂志。近年来主持国家自然科学基金青年科学基金项目和中国博士后科学基金面上一等资助项目，参与多个国家级和省部级项目。
邮箱：zhangshuai2@smu.edu.cn；zhangshuai2@scnu.edu.cn
近年来发表的论文成果
(#: equal contribution; *: corresponding author)
1. Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H*, Zeng JZ*. The Roles of GSK-3b in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Theranostics. 2020 Jan 1;10(3):1230-1244.
2. Zhang S#, Guo M#, Jiang X, Tang L, Wu T, Bi G, Yang X, Fan S, Bi HC*. PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Pharmacol Res. 2023 Feb;188:106666.
3. Shi Z#, To SKY#, Zhang S#, Deng S#, Artemenko M, Zhang M, Tang J, Zeng JZ*, Wong AST*. Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition. Theranostics. 2021 Jan 19;11(7):3376-3391.
4. Cao L#, Zhu Y#, Wang W, Wang G*, Zhang S*, Cheng H*. Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy. Front Bioeng Biotechnol. 2021 Dec 7;9:798882.
5. Zhang M#, Shi Z#, Zhang S, Li X, To SKY, Peng Y, Liu J, Chen S, Hu H, Wong AST*, Zeng JZ*. The Ginsenoside Compound K Suppresses Stem Cell-like Properties and Colorectal Cancer Metastasis by Targeting Hypoxia-driven Nur77-Akt Feed-forward Signaling. Cancers. 2022 Dec 20;15(1):24.
6. Wu Z#, Cheng H#, Liu J#, Zhang S, Zhang M, Liu F, Li Y, Huang Q, Jiang Y, Chen S, Lv L, Li D*, Zeng JZ*. The Oncogenic and Diagnostic Potential of Stanniocalcin 2 in Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2022 Mar 8;9:141-155.
7. Chen X#, Wang S#, Chen Y, Xin H, Zhang S, Wu D, Xue Y, Zha M, Li H, Li K, Gu Z, Wei W*, Ping Y*. Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours. Nat Nanotechnol. 2023 Aug;18(8):933-944.