马晓冬研究员

          联系地址:  华南师范大学脑科学与康复医学研究院

               广东省广州市中山大道西55号

               邮编：510631, 广州, 中国

               Email: maxiaodong@m.scnu.edu.cn

1. 个人简介：

病理与病理生理学博士，研究员、博士生导师，广东省杰出青年医学人才。现任脑科学与康复医学研究院副院长，广东省生态与健康工程中心主任。

2. 主要研究方向

（1）工程化细胞设计构建与疾病治疗；

（2） 单细胞空间转录组学与生物大数据挖掘；

（3）肿瘤神经科学与脑-肿瘤互作调控。

3. 主持课题：

(1) 国家自然科学基金面上项目；项目批准号：“82573531”；主持，起止时间：2026.01-2029.12

(2)  国家自然科学基金面上项目；项目批准号：“82072697”；主持，起止时间：2021.01-2024.12

(3) 分泌型CAR-T细胞体系建立

(4) TNC-CAR-T细胞研发和应用

4. 发表论文

(1) Chen, K., Fu, Q., Zhang, W., Lin, Z., Chen, L., Zhou, Y., Huo, Y., Gao, Z., Wan, H., Wang, C., Huang, X., Zhang, S., Liu, M. & Ma, X. (2026) Extracellular matrix-targeted TNC-scFv armoring enhances CAR T cell persistence and antitumor activity in solid tumors, Sci Adv. 12, eaeh3957.

(2) Duan, J., Fu, Q., Huo, Y., Wang, C., Shen, Y., Zhong, M., Ma, X. & Liu, M. (2026) Critical changes in whole-brain gene networks in response to small-cell lung cancer as revealed by single-nucleus RNA sequencing, Front Immunol. 17, 1860628.

(3) Wang, Y., Duan, J., Zang, L., Sun, T., Lv, H., Liu, F. & Ma, X. (2026) Hyaluronic acid: emerging roles and biomaterial innovations in Alzheimer's and Parkinson's disease therapy, Front Pharmacol. 17, 1772172.

(4) Wang, Y., Cao, Z., Zhang, C., Ying, Y., Zhu, G., Wang, J., Hou, X., Zhang, D., Zheng, Z., Shao, H., Liu, F. & Ma, X. (2026) Oral Sodium Hyaluronate Reshapes Gut Microbiota Composition and Suppresses the LPS-TLR4/NF-kappaB Pathway to Exert Neuroprotection in MPTP-Induced Parkinson's Disease, Int J Mol Sci. 27.

(5) Zhang, W., Chen, K., Ke, Y., Yan, D., Lin, Z., Chen, L., Gao, Z., Shen, Y., Wan, H., Yang, X., Hu, C., Chen, R., Ma, X. & Zhang, S. (2026) Spatial and single-cell transcriptomics reveals senescence-associated changes in MIA-induced ASD male mouse brain, Cell Rep. 45, 117191.

(6) Chen, K. Z., Lin, Z. Y., Chen, L. J., Zhou, Y. X., Zhang, W., Wan, H. Y., Huo, Y. K., Fu, Q., Gao, Z. Q., Cheng, H. W., Ma, X. D. & Zhang, S. S. (2025) TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice, Mil Med Res. 12, 78.

(7) Cao, Z., Li, J., Hu, W., Xu, J., Zhao, F., Wang, Y., Qin, S., Liu, M., Wang, P., Duan, J., Zhou, W., Ding, Z., Tang, S., Ma, X. & Wang, L. (2025) Near-Infrared Imaging Agent ABSi-148 Alleviates CA IX-Mediated Hypoxic Fibrosis in Inflammation-Cancer Transition, Adv Healthc Mater. 14, e2404935.

(8) Li, X., Fu, Q., Zhong, M., Long, Y., Zhao, F., Huang, Y., Zhang, Z., Wen, M., Chen, K., Chen, R. & Ma, X. (2024) Quantitative proteomics of the miR-301a/SOCS3/STAT3 axis reveals underlying autism and anxiety-like behavior, Mol Ther Nucleic Acids. 35, 102136.

(9) Cao, Z., Hu, Z., Wang, Y., Zhao, F., Li, J., Li, R., Hu, W., Liu, B., Tang, S., Wang, P., Li, F., Chen, Z., Wang, L. & Ma, X. (2024) Letrozole-Based Near-Infrared Dynamic Imaging Targeting Ductal-Vascular RhoJ From Pancreatic Intraepithelial Neoplasia to Pancreatic Ductal Adenocarcinoma, Adv Healthc Mater. 13, e2402913.

(10) Liu, M., Zhang, L., Zhong, M., Long, Y., Yang, W., Liu, T., Huang, X. & Ma, X. (2023) CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro, Exp Hematol Oncol. 12, 88.