马晓冬研究员
联系地址: 华南师范大学脑科学与康复医学研究院
广东省广州市中山大道西55号
邮编：510631, 广州, 中国
Email: maxiaodong@m.scnu.edu.cn
1. 个人简介：
南方医科大学，病理与病理生理学博士毕业，广东省杰出青年医学人才，博士生导师，独立PI。美国癌症学会会员，美国基因与细胞治疗学会会员，中国细胞生物学会会员，广东省药学会制药工程专业委员会委员。主持国家和省部级课题8项（4项国家自然基金面上项目，1项广东省自然基金重点项目，1项广东省科技计划国际合作，1项广东省自然科学基金面上项目，1项广州市科技计划）。
2. 主要研究方向
非编码RNA，基因编辑和嵌合抗原受体介导的T细胞免疫治疗。主要研究内容包括：非编码RNA在炎症和肿瘤中的作用机制；CRISPR-Cas9基因编辑和筛选；CAR-T细胞治疗。利用RNA-Seq开展炎性细胞激活在胶质瘤等恶性肿瘤中的作用机制研究；利用基因敲除小鼠模型研究非编码RNA在炎症向恶性肿瘤转化中的作用机制，开展以CRISPR-Cas9和CAR-T技术编辑免疫细胞进行细胞治疗的研究。
3. 主持课题：
(1) 国家自然科学基金面上项目；名称：“基于TNC“一靶双点”的胰腺肿瘤CAR-T靶向治疗新策略”；项目批准号：“82072697”；55万元，主持，起止时间：2021.01.01-2024.12.31
(2) 广东省自然科学基金-重点项目；名称：“高效整合microRNA双向优化CAR-T细胞治疗肿瘤策略研究”，项目批准号：“2017A030311004”，50万，主持，起止时间：2017.05.01-2020.05.01
(3) 国家自然科学基金面上项目；名称：“miR-CAR-T细胞的制备及其功能研究”；项目批准号：“81773249”；60万元，主持，起止时间：2018.01.01-2021.12.31
4. 发表论文
(1) Ming Liu#, Xu Wang#, Wei Li, Xinfang Yu, Pedro Flores-Villanueva, Zijun Y Xu-Monette, Ling Li, Mingzhi Zhang, Ken H Young, Xiaodong Ma*, Yong Li*. Targeting PD-L1 in non-small cell lung cancer using CAR T cells. Oncogenesis. 2020 Aug 13;9(8):72.
(2)Jiexuan Wang#, Xun Li#, Mingtian Zhong#, Yansheng Wang, Liming Zou, Miaomiao Wang, Xiaoli Gong, Xinjie Wang, Chengzhi Zhou*, Xiaodong Ma*, Ming Liu*. miR-301a Suppression within Fibroblasts Limits the Progression of Fibrosis through the TSC1/mTOR Pathway. Mol Ther Nucleic Acids. 2020 May 26;21:217-228.
(3) Xinjie Wang, Mingtian Zhong, Yong Liu, Peixiang Ma, Lu Dang, Qingzhou Meng, Wenwei Wan, Xiaodong Ma, Jia Liu, Guang Yang, Zifeng Yang, Xingxu Huang, Ming Liu. Rapid and Sensitive Detection of COVID-19 Using CRISPR/Cas12a-based Detection with Naked Eye Readout, CRISPR/Cas12a-NER. Sci Bull (Beijing). 2020 May 5. doi: 10.1016/j.scib.2020.04.041.
(4) Xinjie Wang, Pinpin Ji, Huiying Fan, Lu Dang, Wenwei Wan, Siyuan Liu, Yanhua Li, Wenxia Yu, Xiangyang Li, Xiaodong Ma, Xu Ma, Qin Zhao, Xingxu Huang, Ming Liao. CRISPR/Cas12a technology combined with immunochromatographic strips for portable detection of African swine fever virus. Commun Biol. 2020 Feb 11;3(1):62. doi: 10.1038/s42003-020-0796-5
(5) Xiaoli Gong#, Liming Zou#, Miaomiao Wang#, Yingheng Zhang, Shuxian Peng, Mingtian Zhong, Jiankui Zhou, Xun Li*, Xiaodong Ma*. Gramicidin inhibits cholangiocarcinoma cell growth by suppressing EGR4. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):53-59.
(6) Xinjie Wang#, Zhiwei Liu#, GuangLei Li#, Lu Dang, Shisheng Huang, Lei He, Yu’e Ma, Cong Li, Ming Liu, Guang Yang, Xingxu Huang, FeiZhou*, Xiaodong Ma*. Efficient Gene Silencing by Adenine Base Editor Mediated Start Codon Mutation. Molecular Therapy. 2020 Feb 5;28(2):431-440. doi: 10.1016/j.ymthe.2019.11.022.
(7) Lei Wang; Qipan Deng; Ming Liu; Zhaojian Gong; Shanshan Zhang; Hui Hu; Zhongxin Lu; Zijun Xu-Monette; Ken Young; Xiaodong Ma*; Yong Li*. Glyphosate Induces Benign Monoclonal Gammopathy and Promotes Multiple Myeloma Progression in Mice. Journal of Hematology & Oncology, 2019 Jul 5;12(1):70.
(8) Xun Li#, Mingtian Zhong#, Jiexuan Wang#, Lei Wang, Zhanwen Lin, Zhi Cao, Zhujuan Huang, Fengxue Zhang, Yong Li, Ming Liu*, Xiaodong Ma*. miR-301a promotes lung tumorigenesis by suppressing Runx3. Molecular Cancer, 2019 May 23;18(1):99.
(9) LeiWang, Munish Kumar, Qipan Deng, XuWang, MingLiu, Zhaojian Gong, Shanshan Zhang, Xiaodong Ma,Zijun Y. Xu-Monette, Min Xiao, Qing Yi, Ken H.Young, Kenneth S.Ramos, YongLi*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces peripheral blood abnormalities and plasma cell neoplasms resembling multiple myeloma in mice. Cancer Lett. 2019 Jan;440-441:135-144.
(10) Xun Li#, Zhanwen Lin#, Lei Wang #, Qin Liu, Zhi Cao, Zhujuan Huang, Mingtian Zhong, Shuxian Peng, Yingheng Zhang, Yong Li, Xiaodong Ma*. RNA-Seq Analyses of the Role of miR-21 in Acute Pancreatitis. Cellular Physiology and Biochemistry, 2018;51(5):2198-2211.
(11) Mingtian Zhong#, Zhujuan Huang#, Lei Wang#, Zhanwen Lin, Zhi Cao, Xun Li, Fengxue Zhang, Hongqi Wang, Yong Li*, Xiaodong Ma*. Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop. Scientific Reports. 2018 Sep 5;8(1):13291.
(12) Ming Liu*, Xu Wang, Lei Wang, Xiaodong Ma, Zhaojian Gong, Shanshan Zhang, Yong Li*. Targeting the IDO1 pathway in cancer: from bench to bedside. J Hematol Oncol. 2018 Aug 2;11(1):100.
(13) Jiajia Xi#, Qian Huang#, Lei Wang#, Xiaodong Ma, Qipan Deng, Munish Kumar, Zhiyuan Zhou, Ling Li, Zhaoyang Zeng, Ken H. Young, Mingzhi Zhang, Yong Li*. miR-21 deleption in marcrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018 Jun;37(23):3151-3165.
(14) Qian Huang,# Jiajia Xia,# Lei Wang,#, Xu Wang, Xiaodong Ma, Qipan Deng, Yong Lu, Munish Kumar, Zhiyuan Zhou, Ling Li, Zhaoyang Zeng, Ken H. Young, Qing Yi, Mingzhi Zhang, Yong Li*. miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy. J Hematol Oncol. 2018 Apr 23;11(1):58.
(15) Xiaodong Ma*,Daniel J. Conklin, Fenge Li, Zhongping Dai, Xiang Hua, Yan Li, Zijun Y. Xu-Monette, Ken H. Young, Wei Xiong, Marcin Wysoczynski, Srinivas D. Sithu, Sanjay Srivastava, Aruni Bhatnagar, Yong Li*. The oncogenic microRNA miR-21 promotes regulated necrosis in mice. Nat Commun. 2015 May 20;6:7151.
5. 书籍章节撰写：
(1) Xiaodong Ma, Lei Wang, Zhi Cao et al. (2017) Physiological and Pathological Functions of Mammalian MicroRNAs in book entitled “Comprehensive Toxicology 3nd”.