Li XU-E

Insititute for Brain Research and Rehabilitation

South China Normal University

55 Zhongshan West Avenue

Guangzhou, 510631

People’s Republic of China

Mobile: 18607678608 

E-mail: m15817165666@163.com

EDUCATION

2000.08-2002.08   Post Doctor in biology，South China Normal University

1996.03-2000.05   Graduate Student for Doctor Degree in biology，Xi’an  Jiaotong   University.          

1990.09-1993.07  Graduate Student for Master Degree in Chemistry，Xi’an  Jiaotong University.

1982.09-1986.07  Undergraduate Student for Bachelor Degree in Pharmacy,  Xi’an Medical University.

Work Experience

2012.11- Present  Insititute for Brain Research and Rehabilitation，South China Normal University. Professor.

2002.08-2012.11 Vice-dean of School of Life Science, South China Normal University. Professor.

2010.05-2011.09  Cincinnati Children’s Hospital Medical Center, USA. Visiting Scholar.

2008.03-2008.10 School of Life Science, Latrobe University, Australia.         Visiting Scholar.

1993.07-2000.08  Vice-dean of School of Environmental and Chemical Engineering, Dean of “211” Chemical Experiment  Center, Xi’an  Jiaotong University. Lecturer, Associate Professor.

1988.03-1990.09   Xingping Institute for Drug Control, Shaanxi. Pharmacist.    

1986.07-1988.03  Tianjin Institute of Pharmaceutical Research，State Pharmaceutical Administration. Assistant Engineer. 

Main Research projects

1. National Natural Science Foundation of China “Exploring the mechanism of Icraiin on Hematopoietic Stem Cells maintenance in Fanconi Anemia ”. 2017, NO.81370608.

2. National Natural Science Foundation of China “The role of cdc42 in regulating Fanconi Anemia Hematopoietic Stem Cells function”. 2018, NO. 81470288.

3. National Natural Science Foundation of China “Study of niche opening mechanism of hematopoietic stem cells in β-thalassemia major patients using bone marrow transplantation”. 2018, NO. U1401221.

    

Main Publications

1. Li X, Wu L, Zopp M, Kopelov S, Du W. p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells. Stem Cells .  2019 , 37(7):937-947.

2.  Xu J, Li X, Cole A, Sherman Z, Oley F, Du W.  Reduced Cdc42 activity compromises hematopoietic supportive function of Fanconi anemia mesenchymal stromal cells. Stem Cells, 2018, 36(5):785-795.

3.  Li Y, Li X, Cole A, McLaughlin S, Du W.  Icraiin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition. Cell Cycle,  2018,17（3）：367-376 .

4. Li Y, Amarachintha S, Wilson AF, Li X, Du W. Persistence response of Fanconi Anemia hematopoietic stem and progenitor cells to oxidative stress. Cell Cycle,  2017, 16(12):1201-1209.

5. Cai Lin, Chenghai Sun , Xiao Liu, Yiqian Zhou,Muza,,al Hussain,Junting Wan, Minke Li, Li X，Ruiliang Jin, Zhengchao Tu,Jiancun Zhang. Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents. Antiviral Research, 2016,129 :13-20.

6. Jun-Min Shi , Hui-Juan Huang , Sheng-Xiang Qiu , Shi-Xiu Feng and Xu-E Li .Griffipavixanthone from Garcinia oblongifolia Champ Induces Cell Apoptosis in Human Non-Small-Cell Lung Cancer H520 Cells in Vitro. Molecules, 2014, 19, 1422-1431.

7. Li X, Erden O, Li L, Ye Q, Wilson A, Du W. Binding to WGR domain by Salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress. Antioxid Redox Signal, 2014, 20（12）：1853-1865.

8. Li X, Sipple J, Pang QS, Du W. Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance. Blood, 2012, 119（18）: 4162-4173.

9. Du W, Li X, Sipple J, Pang QS. Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML. Blood, 2011, 117（16）: 4243-4252.